Drug Discovery Projects

• mer kinase inhibitors in collaboration with Shelley Earp (LCCC), Doug Graham (U. Colorado) and Gary Johnson (LCCC, Pharmacology)
• IDH1 inhibitors for glioblastoma with Yue Xiong (LCCC, Biochemistry)
• Novel agents for neuropathic pain in collaboration with Mark Zylka (Cell & Molecular Physiology)
• Functionally selective D2 ligands in collaboration with Bryan Roth (Pharmacology/PDSP). 
• ROR2 kinase inhibitors in collaboration with Kimryn Rathmell (Medicine)
• Non-nucleoside DNMT inhibitors in collaboration with William Coleman (LCCC), Cheryl Arrowsmith (U. Toronto, SGC) and Charles Brenner (U. Iowa)
• RGS modulators in collaboration with David Siderovski (Pharmacology)
• Eppin in collaboration with Mike O'Rand (Cell & Developmental Biology)
• GAPDHS in collaboration with Deborah O'Brien (Cell & Developmental Biology)
• CCR7 in collaboration with Jay Coghill (LCCC, Medicine)
• LKB1 in collaboration with Ned Sharpless (LCCC, Medicine)
• IKK epsilon/TBK1 in collaboration with Al Baldwin (LCCC, Biology)
• RecA in collaboration with Scott Singleton (Medicinal Chemistry & Natural Products)
• Rad18 in collaboration with Cyrus Vaziri (Pathology & Laboratory Medicine)

Chemical Biology (Epigenetics) Projects

• Methyl-lysine reader antagonists in collaboration with Cheryl Arrowsmith (U. Toronto, SGC)
• Protein-lysine methyltransferases in collaboration with Cheryl Arrowsmith (U. Toronto, SGC)