Students from the UNC School of Pharmacy will present posters at the American Association of Pharmaceutical Scientists Annual Meetings and Expositions at the San Diego Convention Center on November 13-14.

The students are:

Koji Abe, PhD — Visiting Scholar
Faculty adviser: Kim Brouwer, PhD
Division: Pharmacotherapy and Experimental Therapeutics
Title of Abstract: “In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes — Comparison to In Vivo Biliary Clearance”
Session Date: Tuesday, November 13
Session Time: 1:00-5:00 p.m.
Location: Exhibit Hall

Dan Bow, PhD
Faculty adviser: Kim Brouwer, PhD
Division: Pharmacotherapy and Experimental Therapeutics
Title of Abstract: “P-gp (Abcb1) and Mrp2 (Abcc2) localization in freshly-isolated rat hepatocytes”
Session Date: Tuesday, November 13
Session Time: 1:00-5:00 p.m.
Location: Exhibit Hall

Lucila Garcia-Contreras
Faculty adviser: Athony Hickey, PhD
Title of Abstract: 1) “Pharmacokinetics of Inhaled capreomycin particles in the guinea pig”
2) “Efficacy of inhaled capreomycin particles for the treatment of tuberculosis in the guinea pig”
Session Date: Monday, November 12
Session Time: 1:00-5:00 p.m.
Location: Exhibition Hall

Wujian Ju
Faculty adviser: J Ed Hall, PhD
Division: Molecular Pharmaceutics
Title of Abstract: “Anti-trypanosomal Drug Metabolite DB775 Induces Apoptosis in MCF-7 Cells”
Session Date: Tuesday, November 13
Session Time: 1:00-5:00 p.m.
Location: Exhibit Hall

Beverly Knight
Faculty adviser: Dhiren Thakker, PhD
Division: Molecular Pharmaceutics
Title of Abstract: “Why is Metabolism Higher during Absorptive vs. Secretory Transport across Intestinal Epithelium?”
Session Date: Tuesday, November 13
Session Time: 1:00-5:00 p.m.
Location: Exhibit Hall

Jin K Lee
Faculty adviser: Kim Brouwer, PhD
Division: Pharmacotherapy and Experimental Therapeutics
Title of Abstract: “Modulation of ET-743 Hepatobiliary Disposition by Multidrug Resistance-Associated Proteins (Mrps) May Protect the Liver from Hepatotoxicity”
Session Date: Tuesday, November 13
Session Time: 1:00-5:00 p.m.
Location: Exhibit Hall

Shyh-Dar Li/Sumio Chono/Leaf Huang, PhD
Faculty adviser: Leaf Huang, PhD
Division: Molecular Pharmaceutics
Title of Abstract: “Efficient Gene Silencing in Lung Metastasisby Systemically Delivered siRNA”
Session Date: Tuesday, November 13
Session Time: 9:35 p.m.

Dongmei Lu
Faculty adviser: Athony Hickey, PhD
Title of Abstract: “Pulmonary delivery of recombinant antigen 85B in microparticulate vaccine systems for protection against Tuberculosis”
Session Date: Monday, November 12
Session Time: 8:00 a.m.
Location: Exhibition Hall

Heidi Mansour, PhD/Zhen Xu
Faculty adviser: Athony Hickey, PhD
Title of Abstract: “Characterization of Dry Powder Aerosols of Albuterol Sulfate and Cromolyn Sodium with Various Sugar Carriers Delivered by Standardized Entrainment Tubes.”
Session Date: Wednesday, November 14
Session Time: 1:00-5:00 p.m.
Location: Exhibition Hall

Xin Ming
Faculty adviser: Dhiren Thakker, PhD
Division: Molecular Pharmaceutics
Title of Abstract: “Role of Human Organic Cation/Carnitine Transporter OCTN2 (SLC22A5) in Intestinal Absorption of Zwitterionic Drugs”
Session Date: Tuesday, November 13
Session Time: 1:00-5:00 p.m.
Location: Exhibit Hall

Xin Ming (in collaboration with the Hall Lab)
Faculty adviser: Dhiren Thakker, PhD
Division: Molecular Pharmaceutics
Title of Abstract: “Differential Oral Absorption of the Antitrypanosomal Diamidine Compounds DB829, DB75, and DB820 in Mice”
Session Date: Tuesday, November 13
Session Time: 1:00-5:00 p.m.
Location: Exhibit Hall

Pavan Muttil
Faculty adviser: Athony Hickey, PhD
Title of Abstract: 1) “Spray drying of GFP tagged Pseudomonas aeruginosa in Alginate Microparticles”
                            2) “Spray drying of GFP tagged Pseudomonas aeruginosa in Alginate Microparticles”
Session Date: November, 12
Session Time: 1:00-5:00 p.m.
Location: Exhibition Hall
Session Date: 11/12/2007 1:00 PM 5:00 PM
Exhibition Hall

Will Proctor/Yan Gao, PhD
Faculty adviser: Dhiren Thakker, PhD
Division: Molecular Pharmaceutics
Title of Abstract: “Development of a High Throughput 96-well Transwell MDCK II Cell-based Screen to Identify Intestinal Tight Junction Permeability Enhancers”
Session Date: Tuesday, November 13
Session Time: 1:00-5:00 p.m.
Location: Exhibit Hall

Brandon Swift
Faculty adviser: Kim Brouwer, PhD
Division: Pharmacotherapy and Experimental Therapeutics
Title of Abstract: “Impact of Basolateral Multidrug Resistance-Associated Proteins (Mrp) 3 (Abcc3-/-) and Mrp4 (Abcc4-/-) on the Hepatic Disposition of Fexofenadine (FEX) in Mice”
Session Date: Tuesday, November 13
Session Time: 1:00-5:00 p.m.
Location: Exhibit Hall

Chenchen Wang
Faculty adviser: Athony Hickey, PhD
Title of Abstract: “Preparation, Characterization, and Cellular Response to Microparticles Containing Muramyl Dipeptide and Trehalose Dibehenate.”
Session Date: Monday, November 12
Location: Exhibition Hall

Kristina Wolf, PhD
Faculty adviser: Kim Brouwer, PhD
Division: Pharmacotherapy and Experimental Therapeutics
Title of Abstract: “Effect of Albumin and Free Fatty Acids on the Hepatobiliary Disposition of Digoxin in Sandwich-Cultured Rat Hepatocytes”
Session Date: Wednesday, November 14
Session Time: 8:00 am-12:00 pm
Location: Exhibit Hall

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