Clark Jeffries
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Research interests
Gene expression as control system
Computer-aided function prediction for noncoding RNAs
Deduction of common control mechanisms shared by coordinated miRNAs
Modeling of cell dynamics
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Selected publications (abstracts in PubMed)
Perkins, D.O., Jeffries C., & Sullivan, P.: Expanding the ‘central dogma’: the regulatory role of nonprotein-coding genes and implications for the genetic liability to schizophrenia, Molecular Psychiatry 10 (2005) 69-78.
Jeffries, C., Jarstfer, M., Perkins, D.: Folded RNA from an intron of one gene might inhibit expression of a competing gene, in silico Biology 5 (2005), 0037.
Jeffries, C., Perkins, D., Jarstfer, M.: Systematic discovery of the grammar of translational inhibition by RNA hairpins, Journal of Theoretical Biology 241 (2006) 205-215.
Perkins, D.O., Jeffries, C., Jarskog, L.F., Thomson, J.M., Woods, K., Newman, M.A., Parker, J.S., Jin, J., Hammond, S.M., miRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder, http://genomebiology.com/2007/8/2/R27.
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Clark Jeffries is currently listed as inventor or co-inventor on 53 US Patents, many related to pattern recognition.
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Recent funded research
The Foundation of Hope [D. Perkins (PI)] 2005-2007
"Genetic Control of Neurodevelopment in Schizophrenia: A model based on olfactory neurons from living humans"
To determine if neuronal cells from the olfactory epithelium may provide insights into altered neurodevelopment in individuals with schizophrenia.
Role: Co-Investigator
The Foundation of Hope [D. Perkins (PI)] 2005-2007
"Maturing Human Olfactory Neurons: A Neurodevelopmental Model for Schizophrenia"
To determine if neuronal cells from the olfactory epithelium may provide insights into altered neurodevelopment in individuals with schizophrenia.
Role: Co-Investigator
Pardee Foundation [A. Tropsha (PI)] 2006
“Systematic discovery of automatic gene regulation modules in cell cycle dynamics”
The major goal of this project is experimental investigation of biochemistry of noncoding RNA hairpin molecules as regulatory agents of apoptosis in breast cancer.
Role: Co-Investigator