Primary Faculty  | ken_bastow@unc.edu Associate Professor Research Interest Design and development of topoisomerase inhibitors/ antiviral chemotherapy |  | jarstfer@email.unc.edu Associate Professor Research Interest Synthetic chemistry, molecular biology, and combinatorial chemistry techniques are used to investigate the ribonucleoprotein telomerase, which plays a pivotal role in tumorgenesis. |  | hal_kohn@unc.edu Kenan Professor (Joint appointment with Chemistry Department) Research Interest Examination of the biological mechanism of mitomycin C and bicyclomycin at the molecular level; design and synthesis of new chemotherapeutic agents for the treatment of epilepsy, cancer, and bacterial infections. |  | drewlee@unc.edu Associate Professor (Joint appointment in Department of Biochemistry and Biophysics) Research Interest Using NMR spectroscopy to study the relationship between protein structure and dynamics and how these respond to perturbations such as binding (natural ligands or drugs) and mutation (evolution). |  | khlee@unc.edu Kenan Professor Research Interest Medicinal chemistry, bioactive natural products, new drug discovery and development, and Chinese medicine. |  | jian_liu@unc.edu Associate Professor Research Interest Identification of polysaccharide-based receptor; structure and specificity of a heparan sulfate-based herpes simplex virus 1 receptor; drug targeting; gene therapy. |  | rliu@email.unc.edu Assistant Professor (Joint appointment with Lineberger Comprehensive Cancer Center) Research Interest Functional proteomics approaches to the definition of protein-protein interaction networks, the identification of enzyme-substrate and drug-protein target interactions at a proteome-wide scale, and screening for antibody-like affinity molecules for biomarkers using in vitro protein selection technology. |  | bryan_roth@med.unc.edu Professor (joint appointment with Department of Pharmacology) Director, NIMH Psychoactive Drug Screening Program Research Interest G-protein coupled receptors structure and function ranging from the atomic-level analysis of ligand-receptor interactions to in vivo studies. |  | sfs@email.unc.edu Associate Professor Research Interest Bio-organic and biophysical chemical investigations of the mechanisms of DNA repair, directed evolution of novel enzymes, and development of alternate strategies for targeting drug-resistant pathogenic microorganisms. |  | qszhang@unc.edu Assistant Professor Research Interest Studying endogenous, small molecule-protein interactions and their downstream signaling. | Joint Appointments  | crimmins@email.unc.edu Distinguished Professor and Chair, Department of Chemistry Professor, School of Pharmacy, Division of MCNP (joint appointment) Research Interest Development of new synthetic methods, novel synthetic strategies and total synthesis of biologically active and structurally interesting natural products. |  | khahn@med.unc.edu Distinguished Professor, Department of Pharmacology Professor, School of Pharmacy, Division of MCNP (joint appointment) Research Interest New tools for imaging and precise manipulation of protein activity within living cells and animals; spatio-temporal dynamics of signaling networks: Adhesion, Rho family and MAPK signaling | Research Faculty  | svfrye@email.unc.edu Research Professor Director, Center for Integrative Chemical Biology and Drug Discovery Research Interest Drug design, enzyme inhibitor design, protein kinases | | | bjanzen@email.unc.edu Research Professor Director, Assay Development and Compound Profiling Center for Integrative Chemical Biology and Drug Discovery | | | karthik@email.unc.edu Research Assistant Professor Research Interests Application of chemical encoding schemes to the problems of protein folding and structure based drug design and in generating virtual molecules and predicting structural properties through molecular mechanics and dynamics studies for drug discovery. | | | qunzhaow@email.unc.edu Research Assistant Professor Research Interests Technology that visualizes the behavior of a specific family of enzymes (protein kinases) in living cells. These enzymes have been implicated in a wide variety of disease states, including several forms of cancer. The ability to image the aberrant biochemistry of cells represents an important first step in detecting cancer at its earliest (and therefore most treatable) stage. | Adjunct Faculty | | Arnold Brossi Adjunct Professor | | | Edward Garvey, PhD epgarvey@mindspring.com Adjunct Professor, School of Pharmacy Section head, biochemistry department, GlaxoSmithKline | | | Vijay Gombar, PhD vjgombar@nc.rr.com Adjunct Professor, School of Pharmacy Senior Research Investigator, GlaxoSmithKline | | | Connie Vance, PhD cvance@endacea.nctda.org Adjunct Assistant Professor, School of Pharmacy Senior Research Scientist, Endacea, Inc. | | | Chris Waller, PhD chris.waller@pfizer.com Adjunct Associate Professor, School of Pharmacy Associate Director, (Discovery) Research Informatics, Pfizer, Inc. | | | Stan Young, PhD young@niss.org Adjunct Professor, School of Pharmacy Assistant Director for Bioinformatics, National Institute of Statistical Sciences | | Primary Faculty Research Faculty Adjunct Faculty Faculty Spotlight Read more about Andrew Lee, an expert in NMR spectroscopy |